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Synthesis of 4-allyl-4-arylaminopiperidines and their transformations to spiro[tetrahydroquinoline-2,4′-piperidines]

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

It was established that the yields of a 4-allyl-4-aryl-aminopiperidines in the reaction of 4-aryliminopiperidines with allylmagnesium bromide increase significantly if the reaction is carried out in the presence of a crown ether. A number of previously unknown spiro[tetrahydroquinoline-2,4′-piperidines] were obtained in the cyclization of 4-allyl-4-arylaminopiperidines in the presence of sulfuric acid.

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Authors and Affiliations

  1. Patrice Lumumba Peoples' Friendship University, 117198, Moscow

    N. S. Prostakov, V. V. Kuznetsov & E. E. Stashenko

Authors
  1. N. S. Prostakov
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  2. V. V. Kuznetsov
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  3. E. E. Stashenko
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1514–1519, November, 1989.

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Prostakov, N.S., Kuznetsov, V.V. & Stashenko, E.E. Synthesis of 4-allyl-4-arylaminopiperidines and their transformations to spiro[tetrahydroquinoline-2,4′-piperidines]. Chem Heterocycl Compd 25, 1267–1271 (1989). https://doi.org/10.1007/BF00481521

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  • DOI: https://doi.org/10.1007/BF00481521

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