Archives of oto-rhino-laryngology

, Volume 245, Issue 2, pp 127–131 | Cite as

Postjunctional α2-adrenoceptors in blood vessels of human nasal mucosa

  • K. Ichimura
  • M. -J. Chow
Original Investigations


Human nasal mucosa has various types of blood vessels and is a good tissue for demonstrating receptors for many vasoactive substances, including α-adrenoceptors. In contrast to the large contractile response induced by α2-agonists, our studies have shown that α2-agonists produce a small maximal contraction. This α2-induced response was easily blocked by α1-antagonists, indicating that it is evoked, at least partially, by the stimulation of α1-adrenoceptors. Noradrenaline (NA)-induced contractions could not be abolished by either α1- or α2-antagonists alone, but were almost completely blocked by the combination of both antagonists. This suggests the presence of postjunctional α2-adrenoceptors. The low-maximal responsiveness to α2-agonists and calcium independency of NA-induced contractions were distinct from our former results obtained on canine nasal specimens.

Key words

α-adrenoceptor Nasal blood vessels Vasoconstriction Calcium entry blocker Nasal allergy 


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • K. Ichimura
    • 1
  • M. -J. Chow
    • 2
  1. 1.Department of OtolaryngologyTokyo Metropolitan Fuchu HospitalTokyoJapan
  2. 2.Department of Otolaryngology, Faculty of MedicineThe University of TokyoTokyoJapan

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