Archives of oto-rhino-laryngology

, Volume 245, Issue 2, pp 127–131 | Cite as

Postjunctional α2-adrenoceptors in blood vessels of human nasal mucosa

  • K. Ichimura
  • M. -J. Chow
Original Investigations

Summary

Human nasal mucosa has various types of blood vessels and is a good tissue for demonstrating receptors for many vasoactive substances, including α-adrenoceptors. In contrast to the large contractile response induced by α2-agonists, our studies have shown that α2-agonists produce a small maximal contraction. This α2-induced response was easily blocked by α1-antagonists, indicating that it is evoked, at least partially, by the stimulation of α1-adrenoceptors. Noradrenaline (NA)-induced contractions could not be abolished by either α1- or α2-antagonists alone, but were almost completely blocked by the combination of both antagonists. This suggests the presence of postjunctional α2-adrenoceptors. The low-maximal responsiveness to α2-agonists and calcium independency of NA-induced contractions were distinct from our former results obtained on canine nasal specimens.

Key words

α-adrenoceptor Nasal blood vessels Vasoconstriction Calcium entry blocker Nasal allergy 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Andersson K-E, Bende M (1984) Adrenoceptors in the control of human nasal mucosal blood flow. Ann Otol Rhinol Laryngol 93:179–182Google Scholar
  2. 2.
    Bentley SM, Drew GM, Whiting SB (1977) Evidence for two distinct types of postsynaptic α-adrenoceptor. Br J Pharmacol 61:116P-117PGoogle Scholar
  3. 3.
    Berridge TL, Roach AG (1986) Characterization of α-adrenoceptors in the vasculature of the canine nasal mucosa. Br J Pharmacol 88:345–354Google Scholar
  4. 4.
    Berthelsen S, Pettinger WA (1977) A functional basis for classification of α-adrenergic receptors. Life Sci 21:595–606Google Scholar
  5. 5.
    Constantine JW, Gunnel D, Weeks RA (1980) α1- and α2-vascular adrenoceptors in the dog. Eur J Pharmacol 66:281–286Google Scholar
  6. 6.
    De Mey J, Vanhoutte PM (1981) Uneven distribution of postjunctional alphal- and alpha2-like adrenoceptors in canine arterial and venous smooth muscle. Circ Res 48:875–884Google Scholar
  7. 7.
    Gerold M, Heusler G (1983) α2-adrenoceptor in rat resistance vessel. Naunyn-Schmiedeberg's Arch Pharmacol 322:29–33Google Scholar
  8. 8.
    Ichimura K, Jackson RT (1984) Evidence of α2-adrenoceptors in the nasal blood vessels of the dog. Arch Otolaryngol 110:647–651Google Scholar
  9. 9.
    Langer SZ (1974) Presynaptic regulation of catecholamine release. Biochem Pharmacol 23:1793–1800Google Scholar
  10. 10.
    Lues I, Schumann H-J (1984) B-HT 920 acts as an α1-adrenoceptor agonist in the rabbit aorta under certain in vitro conditions. Naunyn-Schmiedeberg's Arch Pharmacol 325:42–46Google Scholar
  11. 11.
    Miller VM, Vanhoutte PM (1985) Endothelial α2-adrenoceptors in canine pulmonary and systemic blood vessels. Eur J Pharmacol 118:123–129Google Scholar
  12. 12.
    Moulds RF, Jauering RA (1977) Mechanism of prazosin collapse. Lancet I:200–201Google Scholar
  13. 13.
    Schumann H-J, Lues I (1983) Postjunctional α-adrenoceptors in the isolated saphenous vein of the rabbit. Characterization and influence of angiotensin. Naunyn-Schmiedeberg's Arch Pharmacol 323:328–334Google Scholar
  14. 14.
    Seki A, Ichimura K, Ogino T, Kamimura K, Yoshimi K, Suzuki M (1986) Cholinergic receptors in the nasal blood vessels of the dog. Pract Otol (Kyoto) 79:479–483Google Scholar
  15. 15.
    Shoji T, Tsuru H, Shigei T (1983) A regional differnce in the distribution of postsynaptic alpha-adrenoceptor subtypes in canine veins. Naunyn-Schmiedeberg's Arch Pharmacol 324:246–255Google Scholar
  16. 16.
    Starke K (1972) Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart. Naunyn-Schmiedeberg's Arch Pharmacol 274:18–45Google Scholar
  17. 17.
    Timmermans PBMWM, Van Zwieten PA (1981) Vascular smooth muscle contraction inhibited by postsynaptic α2-adrenoceptor activation is induced by an influx of extracellular calcium. Eur J Pharmacol 69:205–208Google Scholar
  18. 18.
    Vanhoutte PM (1982) Heterogeneity of postjunctional vascular α-adrenoceptors and handling of calcium. J Cardiovasc Pharmacol 4:S91-S96Google Scholar
  19. 19.
    Vanhoutte PM, Shepherd JT (1985) Adrenergic pharmacology of human and canine peripheral veins. Fed Proc 44:337–340Google Scholar
  20. 20.
    Wagner RC, Kreiner P, Barnett RJ, Bitensky MW (1972) Biochemical characterization and cytochemical localization of a catecholamine-sensitive adenylate cyclase in isolated capillary endothelium. Proc Natl Acad Sci 69:3175Google Scholar
  21. 21.
    Zimmermann BG (1973) Blockade of adrenergic potentiating effect of angiotensin by 1-SAR-8-ALA-angiotensin II. J Pharmacol Exp Ther 185:486–492Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • K. Ichimura
    • 1
  • M. -J. Chow
    • 2
  1. 1.Department of OtolaryngologyTokyo Metropolitan Fuchu HospitalTokyoJapan
  2. 2.Department of Otolaryngology, Faculty of MedicineThe University of TokyoTokyoJapan

Personalised recommendations