Investigation of nitrogen- and sulfur-containing heterocycles
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The reaction of (3-amino-6-chloro-2-pyridylmercapto)oxalacetic ester with ammonia, benzylamine, morpholine, and piperidine yielded amides, while the reaction of the ester with hydrazine hydrate gave [2-(ethoxycarbonylmethylthio)-3-pyridyl]oxamic acid hydrazide. The benzylamide and morpholide of this acid were obtained by treatment of 2-chloro-6-hydroxy-6,7-di(ethoxycarbonyl)dihydropyridothiazine with the appropriate amines. The reaction of 2-mercapto-3-amino-6-chloropyridine with chlorooxalacetic ester in the presence of alkali yielded potassium [2-(ethoxycarbonylmethylthio)-3-pyridyl]oxamate.
KeywordsNitrogen Ammonia Ester Potassium Hydrate
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