Chemistry of Heterocyclic Compounds

, Volume 7, Issue 11, pp 1397–1400 | Cite as

Investigation of nitrogen- and sulfur-containing heterocycles

XXII. N-(3-pyridyl)oxamic acid derivatives
  • L. G. Levkovskaya
  • T. S. Safonova


The reaction of (3-amino-6-chloro-2-pyridylmercapto)oxalacetic ester with ammonia, benzylamine, morpholine, and piperidine yielded amides, while the reaction of the ester with hydrazine hydrate gave [2-(ethoxycarbonylmethylthio)-3-pyridyl]oxamic acid hydrazide. The benzylamide and morpholide of this acid were obtained by treatment of 2-chloro-6-hydroxy-6,7-di(ethoxycarbonyl)dihydropyridothiazine with the appropriate amines. The reaction of 2-mercapto-3-amino-6-chloropyridine with chlorooxalacetic ester in the presence of alkali yielded potassium [2-(ethoxycarbonylmethylthio)-3-pyridyl]oxamate.


Nitrogen Ammonia Ester Potassium Hydrate 
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Copyright information

© Consultants Bureau 1974

Authors and Affiliations

  • L. G. Levkovskaya
    • 1
  • T. S. Safonova
    • 1
  1. 1.S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical ChemistryMoscow

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