Chemistry of Heterocyclic Compounds

, Volume 4, Issue 5, pp 674–675 | Cite as

Synthesis of the bis(2′-chloroethyl) amide of β-(8-guanyl)propionic acid

  • E. P. Studentsov
  • V. G. Nemets
Article
  • 25 Downloads

Abstract

The synthesis of β-(8-guanyl)propionic acid and its chloride, methyl ester, bis(2′-hydroxyethyl)amide, and bis(2′-chloroethyl)amide has been effected. The latter readily rearranges under certain conditions into 2′-chloroethylaminoethyl β-(8-guanyl)propionate.

Keywords

Methyl Chloride Ester Organic Chemistry Amide 

References

  1. 1.
    W. Ross, Biological Alkylating Agents [Russian translation], Meditsina, Moscow, p. 187, 1964.Google Scholar
  2. 2.
    German patent 213711, Frdl., IX, 1009, 1909.Google Scholar
  3. 3.
    E. S. Golovchinskaya and E. S. Chaman, ZhOKh. 21, 528, 1951.Google Scholar
  4. 4.
    W. Ross and J. Wilson, J. Chem. Soc., 3616, 1959.Google Scholar
  5. 5.
    V. M. Berezovskii and L. I. Strel chunas, Tr. VNII vitaminov, 5, 128, 1954.Google Scholar

Copyright information

© Consultants Bureau 1971

Authors and Affiliations

  • E. P. Studentsov
    • 1
  • V. G. Nemets
    • 1
  1. 1.Lensovet Leningrad Technological InstituteUSSR

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