Abstract
4, 5-Diamino-6-furfurylaminopyrimidine reacts with butyric and valeric anhydrides to give the corresponding 5-N-acyl derivatives. Cyclization of 4-amino-5-butyramido-6-furfurylaminopyrimidine with butyric anhydride gives 6-butyramido-9-furfuryl-8-propylpurine, while cyclization with alcoholic alkali affords the 8-substituted kinetins 6-furfurylamino-8-propyl- and -8-butylpurines, as well as the isomeric 6-amino-8-propyl- and 6-amino-8-butyl-9-furfurylpurines.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
F. Graveri and G. Zoni, Chimica (Milano), 34, 267, 1958; C. A. 53, 395, 1959.
O. N. Kulaeva, Fiziologia rastenii, 2, 229, 1962.
V. M. Cherkasov, G. S. Tret'yakova, N. A. Kapran, and N. N. Nedel'kina, ZhGS. [Chemistry of Heterocyclic Compounds], 1, 170, 1967.
H. C. Koppel and R. K. Robins, J. Org. Chem., 23, 1457, 1961.
G.B. Elion, E. Burgi, and G. H. Hitchings, J. Am. Chem. Soc., 73, 5235, 1951.
J. Fu, E. Chinoporos, and H. Terzian, J. Org. Chem., 30, 1916, 1965.
K. Fries and K. Billig, Ber., 58, 1128, 1925.
R. Hull, J. Chem. Soc., 2214, 1951.
N. Boon, W. Joves, and G. Ramay, J. Chem. Soc., 97, 1951.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cherkasov, V.M., Kurilenko, L.K. Cyclization of 4-amino-5-acylamino-6-furfurylaminopyrimidines. Chem Heterocycl Compd 4, 672–673 (1971). https://doi.org/10.1007/BF00481054
Issue Date:
DOI: https://doi.org/10.1007/BF00481054