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Amidoalkylation of pyrimidine bases of nucleic acids

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of uracil, thymine, and cytosine with acid N-α-chloroalkylamides gave N-substituted derivatives of these compounds. Conditions for the selective amidoalkylation of pyrimidine bases in the 1 position were found.

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Literature Cited

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Authors and Affiliations

  1. Institute of Bioorganic Chemistry, Academy of Sciences of the Ukrainian SSR, 252660, Kiev

    B. M. Khutova, S. V. Klyuchko & L. P. Prikazchikova

Authors
  1. B. M. Khutova
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  2. S. V. Klyuchko
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  3. L. P. Prikazchikova
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 512–515, April, 1991.

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Khutova, B.M., Klyuchko, S.V. & Prikazchikova, L.P. Amidoalkylation of pyrimidine bases of nucleic acids. Chem Heterocycl Compd 27, 407–409 (1991). https://doi.org/10.1007/BF00480839

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  • DOI: https://doi.org/10.1007/BF00480839

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