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Pyrimidines

LXII. Some transformations of cyano derivatives of pyrimidine

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The synthesis of 2-amino-6-cyano-4-methylpyrimidine and 2-amino-4,6-dicyanopyrimidine from the corresponding chloro derivatives is described. It is shown that the reaction of ammonia with chlorodicyanopyrimidine proceeds in two directions one observes substitution of either the chlorine atom or the cyano group.

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Literature cited

  1. V. F. Sedova, V. I. Mamatyuk, V. A. Samsonov, and V. P. Mamaev, Khim. Geterotsikl. Soedin., No. 5, 678 (1977).

    Google Scholar 

  2. A. Boulton, D. Hurst, J. McOmie, and M. Tute, J. Chem. Sod., C, 1202 (1967).

  3. D. Hurst and C. Wells, Tetrahedron Lett., 3919 (1970).

  4. D. Hurst, Tetrahedron Lett., 979 (1970).

  5. G. D. Daves, D. E. O'Brien, L. R. Lewis, and C. C. Cheng, J. Heteorcyclic Chem., 1, 130 (1964).

    Google Scholar 

  6. H. Bredereck, G. Simchen, and P. Speh, Ann., 737, 39 (1970).

    Google Scholar 

  7. O. P. Shkuro and V. P. Mamaev, Izv. Akad. Nauk SSSR, Ser. Khim., 2173 (1971).

  8. H. Yamanaka, Chem. Pharm. Bull., 6, 633 (1958).

    Google Scholar 

  9. H. Yamanaka, Chem. Pharm. Bull., 7, 297 (1959).

    Google Scholar 

  10. Z. Budezinsky and J. Vavrina, Coll. Czech. Chem. Commun., 37, 1721 (1972).

    Google Scholar 

  11. H. Yamanaka, Chem. Pharm. Bull., 6, 638 (1958).

    Google Scholar 

  12. J. Clark and W. Pendergast, J. Chem. Soc., C, 2780 (1969).

  13. T. J. Schwan and H. Tieckelmann, J. Heterocyl. Chem., 2, 202 (1965).

    Google Scholar 

  14. V. P. Manaev and O. A. Zagulyaeva, Zh. Org. Chim., 8, 583 (1972).

    Google Scholar 

  15. Z. Budezinsky and F. Roublik, Coll. Czech. Chem. Commun., 26, 2871 (1961).

    Google Scholar 

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Authors and Affiliations

  1. Novosibirsk Institute of Organic Chemistry, Siberian Branch, Academy of Sciences of the USSR, 630090, Movosibirsk

    O. E. Shkurko & V. P. Mamaev

Authors
  1. O. E. Shkurko
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  2. V. P. Mamaev
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Additional information

See [1] for communication LXI.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 821–824, June, 1977.

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Shkurko, O.E., Mamaev, V.P. Pyrimidines. Chem Heterocycl Compd 13, 669–672 (1977). https://doi.org/10.1007/BF00480678

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  • DOI: https://doi.org/10.1007/BF00480678

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