Advertisement

Chemistry of Heterocyclic Compounds

, Volume 6, Issue 8, pp 978–982 | Cite as

Saturated nitrogen-containing heterocycles

IV. Synthesis and properties of pyrrolidin-2-yl-and cycloalkanopyrrolidin-2-ylpropionic acids
  • A. A. Ponomarev
  • M. V. Noritsina
  • A. P. Kriven'ko
Article

Abstract

A general method for the synthesis of pyrrolidinyland cycloalkanopyrrolidinylpropionic acids by the oxidation of the corresponding heterocyclic alcohols has been developed. Some of those compounds have been converted into the corresponding methyl esters and pyrrolizidin-3-ones. Preliminary pharmacological tests have shown that the pyrrolizidin-3-ones possess a sedative effect.

Keywords

Oxidation Alcohol Methyl Ester Organic Chemistry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature cited

  1. 1.
    A. A. Ponomarev, A. P. Kriven'ko, and M. V. Noritsina, KhGS [Chemistry of Heterocyclic Compounds], 6, 787 (1970).Google Scholar
  2. 2.
    G. Clemo, N. Fletcher, G. Fulton and R. Raper, J. Chem. Soc., 1140 (1950).Google Scholar
  3. 3.
    F. Galinowsky and R. Reichard, Ber., 77, 138 (1944).Google Scholar
  4. 4.
    A. A. Ponomarev, M. V. Noritsina, and A. P. Kriven'ko, KhGS [Chemistry of Heterocyclic Compounds], 2, 923 (1966).Google Scholar
  5. 5.
    A. A. Ponomarev, A. P. Kriven'ko, and M. V. Noritsina, KhGS [Chemistry of Heterocyclic Compounds], 3, 850 (1967).Google Scholar
  6. 6.
    A. A. Ponomarev and M. V. Noritsina, USSR Patent No.193516 (1966); Byull. Izobr., No. 7 (1967).Google Scholar
  7. 7.
    N.V. Khromov-Borisov, A. A. Ponomarev, V. A. Sedavkina, M. V. Noritsina and E. V. Moreva, Abstracts of Lectures at a Conference on Connection between the Pharmacological Activity of Drugs and Their Physicochemical Properties [in Russian] Leningrad, p. 158 (1966).Google Scholar

Copyright information

© Consultants Bureau, a division of Plenum Publishing Corporation 1973

Authors and Affiliations

  • A. A. Ponomarev
    • 1
  • M. V. Noritsina
    • 1
  • A. P. Kriven'ko
    • 1
  1. 1.Chernyshevskii Saratov State UniversityUSSR

Personalised recommendations