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Polarographic study of a triazolobenzodiazepine: Estazolam

Polarographische Untersuchung des Triazolbenzodiazepins Estazolam

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Summary

The polarographic behaviour of 8-chloro-6-phenyl-4H-s-triazolo(4,3-a)-(1,4)-benzodiazepine (estazolam) was studied in the pH range 3–10. The reduction process is irreversible and the current is diffusion-controlled. The linear relationship between current and estazolam concentration permits its polarographic determination in the range 3.4·10−7–1.0·10−4 M. The detection limit was 1.7·10−7 M. The reproducibility of the method in terms of its relative standard deviation was 1.00% and 1.14% using ten determinations at the 2.4·10−5 M and 3.4·10−6 M levels respectively.

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Authors and Affiliations

  1. Departamento de Quimica, Facultad de Ciencias, Universidad del Pais Vasco, E-48080, Bilbao, Spain

    R. M. Jiménez, R. M. Alonso, E. Oleaga & F. Vicente

  2. Departamento de Quimica Analítica, Facultad de Ciencias, Universidad Autónoma de Madrid, E-28034, Madrid, Spain

    L. Hernandez

Authors
  1. R. M. Jiménez
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  2. R. M. Alonso
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  3. E. Oleaga
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  4. F. Vicente
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  5. L. Hernandez
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Jiménez, R.M., Alonso, R.M., Oleaga, E. et al. Polarographic study of a triazolobenzodiazepine: Estazolam. Z. Anal. Chem. 329, 468–471 (1987). https://doi.org/10.1007/BF00480089

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  • DOI: https://doi.org/10.1007/BF00480089

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