Chemistry of Heterocyclic Compounds

, Volume 25, Issue 2, pp 205–208 | Cite as

Novel synthesis of 5-halouracils from 5-mercuri-2,4-dimethoxypyrimidines

  • L. Skul'ski
  • A. Kuyava
  • P. Vrochin'ski


Direct C-mercuration of 2,4-dimethoxypyrimidine with mercury (II) acetate has been shown to give the 5-mercuri-derivative, which is readily converted, either directly or via 5,5′ -mercuribis (2,4-dimethoxypyrimidine), into the 5-halo derivatives. Hydrolysis of the latter with hydrochloric acid affords the 5-halouracils.


Acetate Hydrolysis Mercury Organic Chemistry Hydrochloric Acid 
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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • L. Skul'ski
    • 1
  • A. Kuyava
    • 1
  • P. Vrochin'ski
    • 1
  1. 1.Faculty of PharmacyPolish Academy of MedicineWarsaw

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