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Chemistry of Heterocyclic Compounds

, Volume 25, Issue 2, pp 205–208 | Cite as

Novel synthesis of 5-halouracils from 5-mercuri-2,4-dimethoxypyrimidines

  • L. Skul'ski
  • A. Kuyava
  • P. Vrochin'ski
Article

Abstract

Direct C-mercuration of 2,4-dimethoxypyrimidine with mercury (II) acetate has been shown to give the 5-mercuri-derivative, which is readily converted, either directly or via 5,5′ -mercuribis (2,4-dimethoxypyrimidine), into the 5-halo derivatives. Hydrolysis of the latter with hydrochloric acid affords the 5-halouracils.

Keywords

Acetate Hydrolysis Mercury Organic Chemistry Hydrochloric Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • L. Skul'ski
    • 1
  • A. Kuyava
    • 1
  • P. Vrochin'ski
    • 1
  1. 1.Faculty of PharmacyPolish Academy of MedicineWarsaw

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