Abstract
The kinetics of the hydrolysis of the pseudoglycosidic C-N bond in the N1-derivatives of uracil, thymine, and 5-fluorouracil at various pH values of the medium have been studied. The dependence of the rate of hydrolysis of N1-(tetrahydrofuran 2′-yl)-5-fluorouracil on the temperature has been investigated. The influence of substituants at C5 and N1 of the pyrimidine ring on the stability of the pseudoglycosidic C-N bond has been evaluated.
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For part V, see [10].
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Zhuk, R.A., Berzinya, A.E., Volynkina, G.G. et al. Analogs of the pyrimidine nucleosides. Chem Heterocycl Compd 6, 509–512 (1970). https://doi.org/10.1007/BF00478405
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DOI: https://doi.org/10.1007/BF00478405