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Chemistry of Heterocyclic Compounds

, Volume 7, Issue 1, pp 70–73 | Cite as

Nitrogen- and sulfur-containing heterocycles

XIX. 7H-4-chloro-6-aryl- and 5H-pyrimido[4,5-b][1,4]thiazines
  • M. P. Nemeryuk
  • T. S. Safonova
Article

Abstract

4-Chloro-5-amino- and 4-chloro-5-methylamino-6-phenacylmercaptopyrimidines (II–V and XVI–XX) were obtained by the reaction of 4-chloro-5-amino- and 4-chloro-5-methylamino-6-mercaptopyrimidines (I and XV) with phenacyl halides. It is shown that II–V are cyclized by alkalis to 4-chloro-6-aryl-6-hydroxy-5,6-dihydropyrimido[4,5-b][1,4]thiazines (VI–IXa), while both II–IXa and XVI–XIX, respectively, are converted to 7H-4-chloro-6-aryl- (X–XIII) and 5H-4-chloro-5-methyl-6-arylpyrimido[4,5-b][1,4]thiazines (XX–XXIII) under the influence of acidic reagents.

Keywords

Nitrogen Organic Chemistry Halide Acidic Reagent Phenacyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature cited

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    M. P. Nemeryuk and T. S. Safonova, Khim. Geterotsikl. Soedin., 486 (1967),Google Scholar
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Copyright information

© Consultants Bureau 1973

Authors and Affiliations

  • M. P. Nemeryuk
    • 1
  • T. S. Safonova
    • 1
  1. 1.S. Ordzhonikidze All-Union Scientific-Re search Pharmaceutical-Chemistry InstituteMoscow

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