Abstract
N-Acyl derivatives of imidazole-2-thione and its derivatives were obtained by the reaction of imidazole2-thione and its derivatives with aliphatic anhydrides and with benzoyl chloride in pyridine. The hydrochlorides of 1-methyl and 4 (5)-methyl-S benzoylimidazole-2-thione were obtained by the reaction of 1-methyl- and 4 (5)-methylimidazole-2-thione with benzoyl chloride in dry ethanol. The acylation of imidazole-2-thione and of some of its derivatives was investigated with the aid of their IR spectra, and the importance of the medium in the formation of N- and S -acyl derivatives was shown, as well as the possibility of the migration of substituants from the S — to the N atom under its influence.
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For part VI see [1].
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Simon, I.B., Kovtunovskaya-Levshina, I.I. The synthesis of compounds with antithyroid activity. Chem Heterocycl Compd 2, 584–587 (1966). https://doi.org/10.1007/BF00477526
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DOI: https://doi.org/10.1007/BF00477526