Abstract
The dissociation constants of pyrimidine-5- and pyrimidine-2-carboxylic acids were determined to ascertain the effect of the character of the substituent and its position in the pyrimidine ring. This effect was compared with the effect of substituents on the dissociation constants of the corresponding benzoic acids.
Article PDF
Similar content being viewed by others
Literature cited
V. M. Cherkasov, L. P. Prikazchikova, and L. I. Rybchenko, Khim. Geterotsikl. Soedin., 558 (1972).
L. Fieser and M. Fieser, Current Topics in Organic Chemistry, Van Nos Reinhold (1964).
A. R. Katritzky, Physical Methods in Heterocyclic Chemistry, Academic Press (1963).
German Patent No. 174,941; Frdl., 8, 1238 (1905/1907).
S. Gabriel, Ber., 37, 3642 (1904).
E. Dyer and T. B. Johnson, J. Am. Chem. Soc., 56, 222 (1934).
E. Ballard and T. B. Johnson, J. Am. Chem. Soc., 64, 794 (1942).
J. Baddiley, B. Lythgoe, and A. R. Todd, J. Chem. Soc., 386 (1943).
D. J. Brown and L. N. Short, J. Chem. Soc., 331 (1953).
J. F.W. McOmie and J. M. White, J. Chem. Soc., 4175 (1953).
V. H. Smith and B. E. Christensen, J. Org. Chem., 20, 829 (1953).
A. Holland, British Patent No. 777,465 (1957); Chem. Abstr., 52, 1284 (1958).
M. Robba, Ann. Chim., 5, 351 (1960).
Author information
Authors and Affiliations
Additional information
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 561–562, April, 1972.
Rights and permissions
About this article
Cite this article
Cherkasov, V.M., Prikazchikova, L.P. & Rybchenko, L.I. Investigation of pyrimidine- 5- and pyrimidine-2-carboxylic acids. Chem Heterocycl Compd 8, 512–513 (1972). https://doi.org/10.1007/BF00477437
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00477437