Abstract
The alkylation of benzofuran by isobutylene and tert-butyl alcohol in an autoclave in a flow system on ZnCl2 applied to Al2O3 was studied. The major reaction products are 2- and 3-tert-tert-butylbenzofurans, the ratio of which depends on the conditions used to carry out the reaction. The product yield depends on the acidity of the catalyst used. The predominant formation of 2-tert-butylbenzofuran in the flow system is explained by the isomerization of 3-tert-butylbenzofuran via an intermolecular mechanism.
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See [1,2] for communications I and II.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1020–1022, August, 1971.
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Karakhanov, É.A., Drovyannikova, G.V., Kiseleva, L.A. et al. Catalytic alkylation of benzofurans. Chem Heterocycl Compd 7, 956–958 (1971). https://doi.org/10.1007/BF00477369
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DOI: https://doi.org/10.1007/BF00477369