Fresenius' Zeitschrift für analytische Chemie

, Volume 333, Issue 7, pp 745–746 | Cite as

Simultaneous determination of nicotine and cotinine in plasma by capillary gas liquid chromatography with nitrogen-sensitive detection

  • W. Hammes
  • J. Bittner
  • R. F. Müller
Posters B Chromatography


By the use of structural analogues of nicotine and cotinine as internal standards, the elimination of environmental sources of contamination and an exact clean-up procedure, we were able to develop a rapid and sensitive method which has acceptable accuracy and precision over the concentration range necessary in pharmacokinetic studies.


Chromatography Physical Chemistry Analytical Chemistry Inorganic Chemistry Liquid Chromatography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Gleichzeitige Bestimmung von Nicotin und Cotinin in Plasma mit Hilfe der Capillar-Gas-Chromatographie


  1. 1.
    Davis RA (1986) J Chromatogr Sci 24:134Google Scholar
  2. 2.
    Jacob III E, Wilson M, Benowitz NL (1981) J Chromatogr 222:61Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • W. Hammes
    • 1
  • J. Bittner
    • 1
  • R. F. Müller
    • 1
  1. 1.Department of Pharmacokinetics and MetabolismSchwarz Pharma AGMonheimFederal Republic of Germany

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