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Acid-base conversions of nitrogen heterocycles by the method of NMR spectroscopy. 2. Substituted pyridine- and pyrimidine-1-oxides

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Features of the change in the chemical shifts of the protons of substituted pyridine-, pyrimidine-, 3-hydroxypyridine-, and 5-hydroxypyrimidine-1-oxides, as dependent on the basicity of the medium, were investigated. The ionization constants and the possible forms of the occurrence of the molecules were determined. The character of the influence of the substituents (alkyl, hydroxyl) on the pKa values and the PMR spectral parameters was obtained. The comparison of the results obtained with the data on substituted pyridines and pyrimidines was carried out.

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Authors and Affiliations

  1. Scientific-Research Institute of Pharmacology, Academy of Medical Sciences of the USSR, 125315, Moscow

    V. P. Lezina, M. M. Kozlova, S. B. Gashev, L. V. Gol'tsova, A. U. Stepanyants & L. D. Smirnov

  2. Institute of Chemical Physics, Academy of Sciences of the USSR, 117977, Moscow

    V. P. Lezina, M. M. Kozlova, S. B. Gashev, L. V. Gol'tsova, A. U. Stepanyants & L. D. Smirnov

Authors
  1. V. P. Lezina
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  2. M. M. Kozlova
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  3. S. B. Gashev
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  4. L. V. Gol'tsova
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  5. A. U. Stepanyants
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  6. L. D. Smirnov
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Additional information

For Communication 1, see [1].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1369–1376, October, 1987.

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Lezina, V.P., Kozlova, M.M., Gashev, S.B. et al. Acid-base conversions of nitrogen heterocycles by the method of NMR spectroscopy. 2. Substituted pyridine- and pyrimidine-1-oxides. Chem Heterocycl Compd 23, 1098–1105 (1987). https://doi.org/10.1007/BF00476541

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  • DOI: https://doi.org/10.1007/BF00476541

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