Abstract
The pyridinium cations within betaines can be aminated under mild conditions with aqueous ammonia, ultimately undergoing cyclization to a new tricyclic system: 4-substituted-3,5-dioxopyrimido[5,6-c]-1′-azaquinolizine. Intermediates in the reaction are 4-substituted-3,5-dioxo-2,2-dihydropyrimido[5,6-c]-6H-1′-quinolizines.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 677–680, May, 1987.
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Kochkanyan, R.O., Lukanyuk, S.S. Amination of the pyridinium cations in betaines. Synthesis of substituted pyrimido[5,6-c]-1′-azaquinolizine and its dihydro analogs. Chem Heterocycl Compd 23, 563–566 (1987). https://doi.org/10.1007/BF00476389
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DOI: https://doi.org/10.1007/BF00476389