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Synthesis of 4-substituted 1-methyl(benzyl)-2,5-dimethyl-4-R-aminopiperidines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Schiff base derivatives of 1-methyl(benzyl)-2,5-dimethylpiperidin-4-ones with phenyl, α-pyridyl, benzyl, and Β-hydroxyethyl substituents attached to the imine nitrogen atom react with organometallic compounds to give analogously substituted piperidine bases with methyl, allyl, phenyl, and benzyl substituents in the 4-position. Pure individual geometric isomers of these newly synthesized compounds have been isolated and their structures determined.

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Authors and Affiliations

  1. Patrice Lumumba People's Friendship University, 117923, Moscow

    V. V. Kuznetsov, L. A. Gaivoronskaya, R. M. Romero, E. E. Stashenko, P. I. Zakharov & N. S. Prostatkov

Authors
  1. V. V. Kuznetsov
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  2. L. A. Gaivoronskaya
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  3. R. M. Romero
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  4. E. E. Stashenko
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  5. P. I. Zakharov
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  6. N. S. Prostatkov
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 954–958, July, 1987.

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Kuznetsov, V.V., Gaivoronskaya, L.A., Romero, R.M. et al. Synthesis of 4-substituted 1-methyl(benzyl)-2,5-dimethyl-4-R-aminopiperidines. Chem Heterocycl Compd 23, 783–786 (1987). https://doi.org/10.1007/BF00475651

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  • DOI: https://doi.org/10.1007/BF00475651

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