Chemistry of Heterocyclic Compounds

, Volume 23, Issue 1, pp 102–106 | Cite as

Synthesis of 3-amino-6-methyl-5-ethoxycarbonyl-4,7-dihydrothieno[2,3-b]pyridine derivatives

  • A. A. Krauze
  • é. é. Liepin'sh
  • Yu. é. Pelcher
  • G. Ya. Dubur


The alkylation of piperidinium salts of substituted 1,4-dihydropyridine-2-thiols with chloroacetonitrile or iodoacetamide gave 2-cyanomethylthio- and 2-carbamoylmethylthio-substituted 6-methyl-4-aryl(pyridyl)-5-ethoxycarbonyl-3-cyano-1,4-dihydropyridines, which undergo intramolecular cyclization in basic media to give 3-amino-6-methyl-4-aryl(pyridyl)-5-ethoxycarbonyl-2-cyano(carbamoyl)-4,7-dihydrothieno[2,3-b]pyridines.


Organic Chemistry Pyridine Alkylation Basic Medium Piperidinium 
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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • A. A. Krauze
    • 1
  • é. é. Liepin'sh
    • 1
  • Yu. é. Pelcher
    • 1
  • G. Ya. Dubur
    • 1
  1. 1.Institute of Organic SynthesisAcademy of Sciences of the Latvian SSRRiga

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