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Chemistry of Heterocyclic Compounds

, Volume 23, Issue 1, pp 102–106 | Cite as

Synthesis of 3-amino-6-methyl-5-ethoxycarbonyl-4,7-dihydrothieno[2,3-b]pyridine derivatives

  • A. A. Krauze
  • é. é. Liepin'sh
  • Yu. é. Pelcher
  • G. Ya. Dubur
Article

Abstract

The alkylation of piperidinium salts of substituted 1,4-dihydropyridine-2-thiols with chloroacetonitrile or iodoacetamide gave 2-cyanomethylthio- and 2-carbamoylmethylthio-substituted 6-methyl-4-aryl(pyridyl)-5-ethoxycarbonyl-3-cyano-1,4-dihydropyridines, which undergo intramolecular cyclization in basic media to give 3-amino-6-methyl-4-aryl(pyridyl)-5-ethoxycarbonyl-2-cyano(carbamoyl)-4,7-dihydrothieno[2,3-b]pyridines.

Keywords

Organic Chemistry Pyridine Alkylation Basic Medium Piperidinium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • A. A. Krauze
    • 1
  • é. é. Liepin'sh
    • 1
  • Yu. é. Pelcher
    • 1
  • G. Ya. Dubur
    • 1
  1. 1.Institute of Organic SynthesisAcademy of Sciences of the Latvian SSRRiga

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