Abstract
The pKa values have been determined spectrometrically of the 5, 8, 8-trimethyl-2, 4, 6-trioxo-1, 2, 3, 4, 5, 6, 7, 8, 9, 10-decahydropyrimido[4, 5-b]quinolines Ia–Ic, the 5, 8, 8-trimethyl-2, 4, 6-trioxo-1, 2, 3, 4, 6, 7, 8 9-octahydropyrimido [4, 5-b]quinolines IIa and IIb, the 2, 4, 6-trioxo-5-phenyl-1, 2, 3, 4, 5, 11-hexahydro-11-azapyrimido [4, 5-b]fluorenes IIIa–IIIc, and the 4-amino uracils IVa–IVc. The following sequences of the dissociation of the protons attached to the nitrogen atoms have been established: for I, N(1) > N(10) > N(3); for II, N(1) > N(3); for III, N(11) > N(1) > N(3); and for IV, N(3) > N(1).
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References
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Stankevich, E.I., Popelis, Y.Y., Grinshtein, E.E. et al. Acid dissociation constants of some nitrogen-containing multinuclear systems. Chem Heterocycl Compd 6, 116–118 (1970). https://doi.org/10.1007/BF00475441
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DOI: https://doi.org/10.1007/BF00475441