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Substitution in the barbituric acid molecule

IV. Reactions with hydrazines and carboxylic acid hydrazides

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Condensation of barbituric acid with hydrazines with carboxylic acid hydrazides affords barbituric acid 2-hydrazones, as a result of the ketonic character of the 2-carbonyl group. Similarly, condensation with hydrazine hydrate gives the corresponding azine.

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References

  1. V. M. Vvedenskii, M. P. Makukha, and L. G. Timoshinina, KhGS, collections, 1970 (in press).

  2. V. M. Vvedenskii, V. G. Ponomarenko, and M. P. Makukha, USSR patent no. 174630, 1965; Byull. Izobr., no. 19, 1965.

  3. T. K. Fukuhara and D. W. Wisser, J. Am. Chem. Soc., 77, 2393, 1955.

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Authors and Affiliations

  1. Grodno Institute of Medicine, USSR

    V. M. Vvedenskii & A. I. Zhvalevskaya

Authors
  1. V. M. Vvedenskii
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  2. A. I. Zhvalevskaya
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For part III, see [1].

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Vvedenskii, V.M., Zhvalevskaya, A.I. Substitution in the barbituric acid molecule. Chem Heterocycl Compd 6, 91–92 (1970). https://doi.org/10.1007/BF00475434

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  • DOI: https://doi.org/10.1007/BF00475434

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