Chemistry of Heterocyclic Compounds

, Volume 24, Issue 3, pp 290–294 | Cite as

Synthesis of phenoxypyridines under phase transfer catalysis conditions

  • é. M. Abele
  • Yu. Sh. Gol'dberg
  • M. P. Gavars
  • A. P. Gaukhman
  • M. V. Shimanskaya


Reactions of halopyridines with alkali metal phenoxides in a two phase liquid-solid catalytic system, rather than in a liquid-liquid phase transfer catalytic system, make it possible to prepare 2-, 3-, and 4-phenoxypyridines from unactivated bromo- or chloropyridines and 2-chloropicolines. In polyhalogenated pyridines only α- and γ-halogen atoms undergo substitution. 7, 8-Dibromo-6-azaphenoxane has been prepared by the reaction of 2,3,5,6-tetrabromopyridine with the dipotassium salt of pyrocatechol.


Organic Chemistry Catalysis Pyridine Alkali Metal Catalytic System 
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Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • é. M. Abele
    • 1
  • Yu. Sh. Gol'dberg
    • 1
  • M. P. Gavars
    • 1
  • A. P. Gaukhman
    • 1
  • M. V. Shimanskaya
    • 1
  1. 1.Institute of Organic SynthesisAcademy of Sciences of the Latvian SSRRiga

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