Chemistry of Heterocyclic Compounds

, Volume 8, Issue 3, pp 285–287 | Cite as

New synthesis of desthio biotin

  • B. P. Fabrichnyi
  • I. F. Shalavina
  • S. M. Kostrova
  • Ya. L. Gol'dfarb
Article
  • 52 Downloads

Abstract

A method for the synthesis of desthiobiotin was developed. It is based on the reductive desulfurization of the lactam of δ -(5-bromo-4-nitro-3-amino-2-thienyl)valeric acid, saponification of the resulting ɛ-(1-aminoethyl-ɛ-enantholactam to 7,8-diaminopelargonic acid, and condensation of the latter with phosgene or urea.

Keywords

Urea Organic Chemistry Biotin Desulfurization Lactam 

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Copyright information

© Consultants Bureau 1974

Authors and Affiliations

  • B. P. Fabrichnyi
    • 1
  • I. F. Shalavina
    • 1
  • S. M. Kostrova
    • 1
  • Ya. L. Gol'dfarb
    • 1
  1. 1.N. D. Zelinskii Institute of Organic ChemistryAcademy of Sciences of the USSRMoscow

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