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Purine nucleoside analogs. 6. Chlorination of acycloguanosine and some of its derivatives with thionyl chloride

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of 9- and 7-(2-hydroyethoxymethyl)guanines and some of their derivatives with thionyl chloride inhexamethylphosphorustriamide was investigated. 9- and 7-(2-Chloroethoxymethyl)- and 8-chloro-, 8-bromo-, and 8-mercapto-9-(2-chloroethoxymethyl)guanines were synthesized. The structure of the compounds was confirmed by the UV and ESR spectra.

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Authors and Affiliations

  1. Institute of Organic Synthesis, Latvian Academy of Sciences, 226006, Riga

    M. A. Madre, R. A. Zhuk & M. Yu. Lidak

Authors
  1. M. A. Madre
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  2. R. A. Zhuk
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  3. M. Yu. Lidak
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Additional information

See [1] for Communication 5.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 671–673, May, 1992.

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Madre, M.A., Zhuk, R.A. & Lidak, M.Y. Purine nucleoside analogs. 6. Chlorination of acycloguanosine and some of its derivatives with thionyl chloride. Chem Heterocycl Compd 28, 567–569 (1992). https://doi.org/10.1007/BF00475258

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  • DOI: https://doi.org/10.1007/BF00475258

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