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Synthesis of 4-oxo-3,4,5,6-tetrahydrospiro(benzo[h]quinazoline-5,1-cyclohexane) derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of4-acylamino-3-cyano-1,2-dihydrospiro(naphthalene-2,1-cyclohexanes) with hydrogen chloride yields 2-substituted 4-oxo-3,4,5,6-tetrahydrospiro(benzo[h]quinazoline-5,1-cyclohexanes). It was found that when the latter are condensed with methyl iodide, N-alkylation takes place exclusively. Alkylation with ethyl iodide in analogous conditions yields a mixture of O- and N-substituted products.

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Literature cited

  1. A. M. Tripathi, B. A. Tekwani, R. Sen, and S. Chatak, Ind. J. Exp. Biol., 23, 452 (1985).

    Google Scholar 

  2. T. Hirota, K. Kawanishi, K. Sasaki, T. Namba, A. Iwadoh, and Sh. Hayakawa, J. Heterocycl. Chem., 23, 685 (1986).

    Google Scholar 

  3. T. Hirota, K. Kawanishi, and K. Sasaki, Heterocycles, 24, 1119 (1986).

    Google Scholar 

  4. J. Krapcho and Ch. F. Twek, US Patent No. 3,925,384; Chem. Abstr., 84, 90175X (1976).

    Google Scholar 

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Authors and Affiliations

  1. Institute of Precision Organic Chemistry, Armenian Academy of Sciences, 375014, Erevan

    A. I. Markosyan, M. G. Oganisyan & R. A. Kuroyan

Authors
  1. A. I. Markosyan
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  2. M. G. Oganisyan
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  3. R. A. Kuroyan
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 658–661, May, 1992.

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Markosyan, A.I., Oganisyan, M.G. & Kuroyan, R.A. Synthesis of 4-oxo-3,4,5,6-tetrahydrospiro(benzo[h]quinazoline-5,1-cyclohexane) derivatives. Chem Heterocycl Compd 28, 556–559 (1992). https://doi.org/10.1007/BF00475256

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  • DOI: https://doi.org/10.1007/BF00475256

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