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4-Hydroxy-2-quinolones. 4. selection of the optimum path for synthesis of n-r-substituted 4-hydroxy-2-quinolone-3-carboxylic acid amides

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A comparison of several methods of preparation of N-R-substituted 4-hydroxy-2-quinolone-3-carboxylic acid amides showed that intramolecular cyclization of 2-carbalkoxymalonanilic acid ethyl esters with simultaneous amidation is the most rational method.

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Literature cited

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Authors and Affiliations

  1. Khar'kov Pharmaceutical Institute, 310002, Khar'kov

    I. V. Ukrainets, P. A. Bezuglyi, V. I. Treskach & A. V. Turov

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  1. I. V. Ukrainets
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  2. P. A. Bezuglyi
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  3. V. I. Treskach
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  4. A. V. Turov
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Additional information

See [1] for Communication 3.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 640–642, May, 1992.

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Ukrainets, I.V., Bezuglyi, P.A., Treskach, V.I. et al. 4-Hydroxy-2-quinolones. 4. selection of the optimum path for synthesis of n-r-substituted 4-hydroxy-2-quinolone-3-carboxylic acid amides. Chem Heterocycl Compd 28, 538–540 (1992). https://doi.org/10.1007/BF00475252

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  • DOI: https://doi.org/10.1007/BF00475252

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