Chemistry of Heterocyclic Compounds

, Volume 8, Issue 7, pp 906–909 | Cite as

Investigations in the imidazole series

LXXVII. Action of α-halo aldehydes and their acetals on 8-thio derivatives of purine and theophylline
  • M. I. Yurchenko
  • B. V. Kurmaz
  • P. M. Kochergin
Article
  • 31 Downloads

Abstract

Purinyl(theophyllinyl)-8-mercapto aldehydes and their acetals were synthesized by the reaction of 8-thio derivatives of purine and theophylline with α-halo aldehydes and their acetals. The IR spectra demonstrated that the indicated aldehydes exist in the solid state as tautomeric forms — 3-hydroxy derivatives of thiazolino[2,3-f]purines(xanthines). Dehydration of the latter gave thiazolo[2,3-f]purine, 6,8-dimethylthiazolo[2,3-f]xanthine, and their 2-alkyl-substituted derivatives. The structures of the three-ring compounds were established by reductive desulfuration to 7-alkyl-substituted purines and theophyllines.

Keywords

Acetal Organic Chemistry Aldehyde Solid State Dehydration 

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Copyright information

© Consultants Bureau 1974

Authors and Affiliations

  • M. I. Yurchenko
    • 1
  • B. V. Kurmaz
    • 1
  • P. M. Kochergin
    • 1
  1. 1.Zaporozhe State Medical Institute. S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical-Chemistry InstituteUSSR

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