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Investigation of nitrogen- and sulfur-containing heterocycles

XXIII. Synthesis of 6-amino derivatives of pyrimido[4,5-b]-,pyrazino[2,3-b]-, and pyrido[2,3-b]-1,4-thiazines

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Abstract

The reaction of o-aminomercapto derivatives of pyrimidine, pyrazine, and pyridine, with α-halo acid nitriles was investigated. The corresponding cyanoalkylthio heterocycles, which were converted to 6-amino derivatives of pyrimido[4,5-b]-, pyrazino[2,3-b]-, and pyrido-[2,3-b]-1,4-thiazines, were obtained. The structures of the substances obtained were confirmed by IR, UV, and PMR spectroscopy.

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Literature cited

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical-Chemistry Institute, Moscow

    T. S. Safonova, M. P. Nemeryuk, L. A. Myshkina & N. I. Traven'

Authors
  1. T. S. Safonova
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  2. M. P. Nemeryuk
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  3. L. A. Myshkina
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  4. N. I. Traven'
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Additional information

See [10] for communication XXII.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 944–948, July, 1972.

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Safonova, T.S., Nemeryuk, M.P., Myshkina, L.A. et al. Investigation of nitrogen- and sulfur-containing heterocycles. Chem Heterocycl Compd 8, 859–863 (1972). https://doi.org/10.1007/BF00475219

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  • DOI: https://doi.org/10.1007/BF00475219

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