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Anomalous nucleosides

VII. Synthesis of 6-azacytidine and its derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A preparative synthesis of the antimetabolite 6-azacytidine is described which involves the amination under mild conditions without the use of an autoclave of 2′, 3′, 5′-tri-O-acyl-4-thip-6-azauridines with the isolation of the intermediate 2′, 3′, 5′-tri-O-acyl-6-azacytidines and subsequent elimination of the protective groups at room temperature.

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Authors and Affiliations

  1. Zabolotnyi Institute of Microbiology and Virology, AS UkrSSR, Kiev

    V. P. Chernetskii & I. V. Alekseeva

Authors
  1. V. P. Chernetskii
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  2. I. V. Alekseeva
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For communication VI, see [10].

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Chernetskii, V.P., Alekseeva, I.V. Anomalous nucleosides. Chem Heterocycl Compd 3, 861–863 (1967). https://doi.org/10.1007/BF00474891

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  • DOI: https://doi.org/10.1007/BF00474891

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