Abstract
A method for the synthesis of esters of β-thiophenecarboxylic acids and diethyl 3-methyl-2,4-thiophenedicarboxylate by the deamination of derivatives of 2-amino-3-ethoxycarbonylthiophene has been proposed. Ethyl tetrahydrothionaphthene-3-carboxylate has been converted by dehydrogenation on heating with sulfur into ethyl thionaphthene-3-carboxylic acid. The corresponding acids have been obtained by the hydrolysis of the esters. A number of dialkylaminoalkyl esters has been obtained from β-thiophenecarboxylic acids and 3-methyl-2, 4-thiophenedicarboxylic acid via the acid chlorides.
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Shvedov, V.I., Ryzhkova, V.K. & Grinev, A.N. A new method for the synthesis of esters of β-thiophenecarboxylic acids. Chem Heterocycl Compd 3, 789–792 (1967). https://doi.org/10.1007/BF00474869
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DOI: https://doi.org/10.1007/BF00474869