Chemistry of Heterocyclic Compounds

, Volume 10, Issue 12, pp 1477–1480 | Cite as

Analogs of purine nucleosides and purine mono- and polynucleotides

II. Substituted α-(9-purinyl)-γ-butyrolactones
  • S. A. Giller
  • I. N. Getsova
  • I. N. Goncharov
  • L. N. Petrulyanis
  • L. I. Mironova
  • G. F. Nazarova
  • é. I. Bruk
Article

Abstract

Reactions of 6-chloropurine and adenine with α-bromo-γ-butyrolactone gave α-(9-purinyl)-γ-butyrolactones substituted in the 6 position of the purine ring, the reduction of which with sodium borohydride gave the corresponding 6-substituted 9-(1,4-dihydroxy-2-butyl)purines. Amination of α-(6-chloro-9-purinyl)-γ-butyrolactone proceeds primarily with cleavage of the lactone ring.

Keywords

Sodium Organic Chemistry Adenine Purine Nucleoside 

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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • S. A. Giller
    • 1
  • I. N. Getsova
    • 1
  • I. N. Goncharov
    • 1
  • L. N. Petrulyanis
    • 1
  • L. I. Mironova
    • 1
  • G. F. Nazarova
    • 1
  • é. I. Bruk
    • 1
  1. 1.Institute of Organic SynthesisAcademy of Sciences of the Latvian SSRRiga

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