Abstract
Reactions of 6-chloropurine and adenine with α-bromo-γ-butyrolactone gave α-(9-purinyl)-γ-butyrolactones substituted in the 6 position of the purine ring, the reduction of which with sodium borohydride gave the corresponding 6-substituted 9-(1,4-dihydroxy-2-butyl)purines. Amination of α-(6-chloro-9-purinyl)-γ-butyrolactone proceeds primarily with cleavage of the lactone ring.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
S. A. Giller, I. N. Goncharova, I. N. Getsova, L. I. Mironova, G. F. Nazarova, é. I. Bruk, and L. N. Petrulyanis, Khim. Geterotsikl. Soedin., 1674 (1974).
M. Yu. Lidak, Ya. Ya. Shluke, B. V. Zarinya, and S. E. Poritere, Khim. Geterotsikl. Soedin., 262 (1971).
S. A. Giller, R. A. Zhuk, and Ya. G. Nashatyr', Khim. Geterotsikl. Soedin., 557 (1968).
M. Miyaki, A. Saito, and B. Shimizu, Chem. Pharm. Bull. Tokyo, 18, 2459 (1970).
N. Ueda, T. Kauabata, and K. Takemoto, J. Heterocyclic Chem., 8, 827 (1971).
J. E. Livak, E. C. Britton, J. C. Vander Weele, and M. F. Murray, J. Amer. Chem. Soc., 67, 2219 (1945).
A. A. Shazhenov, Ch. Sh. Kadyrov, and P. Kurbanov, Khim. Geterotsikl. Soedin., 641 (1972).
H. U. Frusk and H. S. Isbell, J. Amer. Chem. Soc., 78, 2844 (1956).
Author information
Authors and Affiliations
Additional information
See [1] for communication I.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1680–1683, December, 1974.
Rights and permissions
About this article
Cite this article
Giller, S.A., Getsova, I.N., Goncharov, I.N. et al. Analogs of purine nucleosides and purine mono- and polynucleotides. Chem Heterocycl Compd 10, 1477–1480 (1974). https://doi.org/10.1007/BF00474334
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00474334