Chemistry of Heterocyclic Compounds

, Volume 15, Issue 3, pp 265–268 | Cite as

Synthesis of pyridine and pyrimidine derivatives by reaction of pyrylium salts with ureas, thioureas, and isothioureas

  • é. A. Zvezdina
  • M. P. Zhdanova
  • G. N. Dorofeenko


2,4,6-Triphenylpyrylium perchlorate is converted to 2,4,6-triphenylpyridine in reactions with urea and N-acetyl- and N,N-dimethylureas, whereas it is converted to 1,2,4,6-tetraphenylpyridinium perchlorate on reaction with N,N′-diphenylurea. The reaction of pyrylium perchlorates with thiosemicarbazide and semicarbazide leads to 1-thiocarbamido- and 1-carbamidopyridinium salts. The latter reacts with 2,4,6-triphenylpyrylium perchlorate to give 1-aminopyridinium salts, which were acylated with acetic anhydride. Difficult-to-obtain 2-alkylthio-4,6-diarylpyrimidines were synthesized in 40–93% yields by the reaction of 2,4,6-triarylpyrylium salts with S-alkylisothioureas.


Acetic Urea Organic Chemistry Pyridine Anhydride 
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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • é. A. Zvezdina
    • 1
  • M. P. Zhdanova
    • 1
  • G. N. Dorofeenko
    • 1
  1. 1.Scientific-Research Institute of Physical and Organic ChemistryRostov State UniversityRostov-on-Don

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