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A new pyrimidine analog of m-tyrosine

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Synthesis of the hitherto unknown β-(6-hydroxypyrimidyl-4)alanine, a pyrimidine analog of m-tyrosine, is effected. It is based on conversion of ethyl β-(6-methoxypyrimidyl-4)pyrotartrate to an α-hydroxyimino derivative followed by reduction of the latter in acid medium. The synthesis of β-(6-hydroxypyrimidyl-4)alanine completes the preparation of the series of all theoretically possible pyrimidine analogs of m-tyrosine.

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Authors and Affiliations

  1. Lomonosov Moscow State University, USSR

    Yu. P. Shvachkin, M. K. Berestenko & Lieh Tong Hai

Authors
  1. Yu. P. Shvachkin
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  2. M. K. Berestenko
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  3. Lieh Tong Hai
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Additional information

A comparative study of amino acids I-Ic is in hand. The authors are very grateful to Prof. M. A. Prokof'ev for his continued interest in the present work.

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Shvachkin, Y.P., Berestenko, M.K. & Hai, L.T. A new pyrimidine analog of m-tyrosine. Chem Heterocycl Compd 1, 422–423 (1966). https://doi.org/10.1007/BF00473827

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  • DOI: https://doi.org/10.1007/BF00473827

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