Chemistry of Heterocyclic Compounds

, Volume 1, Issue 3, pp 300–304 | Cite as

Research on 1, 2, 4-triazoles

V. 4-Phenyl- 2, 2, 4-triazolinethione-3 alkylation products
  • I. L. Shegal
  • I. Ya. Postovskii


Alkylation of 4-phenyl-1, 2, 4-triazolinethione-3 with halogen compounds gives sulfides, which oxidize to sulfones. Unlike the corresponding tetrazole derivatives they do not exhibit antitubercular activity. The oxidation of 4-phenyl-3-carboxymethylthio-1, 2, 4-triazole is investigated. Permanganate oxidation is accompanied by decarboxylation and formation of 4-phenyl-1, 2, 4-triazolylmethylsulfone-3, while oxidation with hydrogen peroxide gives 4-phenyl-1, 2, 4-triazolinone-3. It is found that treatment of 4-phenyl-3-carboxymethylthio-1, 2, 4-triazole with acetic anhydride gives di(4-phenyl-3-methylenethio-1, 2, 4-triazoline)ketone, possibly via formation of an anhydro- derivative.


Oxidation Hydrogen Acetic Hydrogen Peroxide Sulfone 
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Copyright information

© The Faraday Press, Inc. 1966

Authors and Affiliations

  • I. L. Shegal
    • 1
  • I. Ya. Postovskii
    • 1
  1. 1.Kirov Urals Polytechnic InstituteSverdlovsk

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