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Chemistry of Heterocyclic Compounds

, Volume 1, Issue 3, pp 300–304 | Cite as

Research on 1, 2, 4-triazoles

V. 4-Phenyl- 2, 2, 4-triazolinethione-3 alkylation products
  • I. L. Shegal
  • I. Ya. Postovskii
Article
  • 57 Downloads

Abstract

Alkylation of 4-phenyl-1, 2, 4-triazolinethione-3 with halogen compounds gives sulfides, which oxidize to sulfones. Unlike the corresponding tetrazole derivatives they do not exhibit antitubercular activity. The oxidation of 4-phenyl-3-carboxymethylthio-1, 2, 4-triazole is investigated. Permanganate oxidation is accompanied by decarboxylation and formation of 4-phenyl-1, 2, 4-triazolylmethylsulfone-3, while oxidation with hydrogen peroxide gives 4-phenyl-1, 2, 4-triazolinone-3. It is found that treatment of 4-phenyl-3-carboxymethylthio-1, 2, 4-triazole with acetic anhydride gives di(4-phenyl-3-methylenethio-1, 2, 4-triazoline)ketone, possibly via formation of an anhydro- derivative.

Keywords

Oxidation Hydrogen Acetic Hydrogen Peroxide Sulfone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Faraday Press, Inc. 1966

Authors and Affiliations

  • I. L. Shegal
    • 1
  • I. Ya. Postovskii
    • 1
  1. 1.Kirov Urals Polytechnic InstituteSverdlovsk

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