Investigations on 2, 1, 3-thia- and selenadiazoles
- 54 Downloads
Nitration and nitrosation of 4-hydroxy-5-methyl-benzo-2, 1, 3-thiadiazole gives 4-hydroxy-5-methyl-7-nitro-and 4-hydroxy-5-methyl-7-nitrosobenzo-2, 1, 3-thiadiazoles. Oxidation of the latter, or of 4,7-diamino-5-methylbenzo-2,1,3-thiadiazole gives 5-methyl-4,7-dihydroxy-2, 1, 3-thiadiazole, forming derivatives with sodium bisulfite or hydroxylamine, and reduced by sodium dithionite to 5-methyl-4, 7-dihydroxybenzo-2, 1, 3-thiadiazole. The latter is also obtained by diazotizing 5-methyl-4-hydroxy-7-aminobenzo-2, 1, 3-thiadiazole, and decomposing the diazonium salt. Nitration of 4-ethoxybenzo-2, 1, 3-thiadiazole with sodium ethoxide gives 4-ethoxy-7-aminobenzo-2, 1, 3-thiadiazole, acetylated to 4-ethoxy-7-acetaminobenzo-2, 1, 3-thiadiazole.
KeywordsOxidation Sodium Organic Chemistry Nitration Hydroxylamine
Unable to display preview. Download preview PDF.
- 1.V. G. Pesin, I; A. Belen'kaya-Lotsmanenko, and A. M. Khaletskii, ZhOKh, 34, 3763, 1964.Google Scholar
- 2.V. M. Berezovskii, Chemistry of the Vitamins [in Russian], Pishchepromizdat, Moscow, 1959.Google Scholar
- 3.V. G. Pesin, V. A. Sergeev, and A. M. Khaletskii, ZhOKh, 34, 1986, 1964.Google Scholar
- 4.V. G, Pesin, A. M. Khaletskii, and V, A. Sergeev, ZhOKh, 33, 1759, 1963.Google Scholar
- 5.V. G. Pesin, A. M Khaletskii, and I. A. Lotsmanenko, ZhOKh, 33, 1746, 1963.Google Scholar