, Volume 63, Issue 1, pp 21–27 | Cite as

Allergic bronchopulmonary aspergillosis (ABPA): Studies on the general and specific humoral response

  • R. S. Sandhu
  • E. J. Bardana
  • Z. U. Khan
  • D. M. Dordevich


Serum specimens from 138 patients suffering from chronic respiratory disorders including 63 with allergic bronchopulmonary aspergillosis (ABPA), 20 with suspected ABPA, 25 with pulmonary tuberculosis, 14 with bronchial asthma, 10 with chronic bronchitis and 6 with miscellaneous pulmonary conditions were studied for circulating antibodies to Aspergillus. The ammonium sulfate test was employed with an iodine-125 labeled mycelial component derived from Aspergillus fumigatus. When compared to normal controls from the same area, this test indicated that sera from 82 per cent of patients with ABPA had elevated binding titers to the radiolabeled antigenic component. Immunodiffusion using a culture filtrate antigen from A. fumigatus, revealed precipitating antibody to this fungus in 89 per cent of sera from ABPA patients. The majority of patients with ABPA demonstrated marked elevations of total serum IgE, moderate elevations of serum IgA and IgD and slightly increased levels of IgG and IgM.


Aspergillus Bronchitis Ammonium Sulfate Aspergillosis Culture Filtrate 
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Copyright information

© Kluwer Academic Publishers 1978

Authors and Affiliations

  • R. S. Sandhu
    • 1
  • E. J. Bardana
    • 2
  • Z. U. Khan
    • 1
  • D. M. Dordevich
    • 2
  1. 1.Department of Medical Mycology, Vallabhbhai Patel Chest InstituteUniversity of DelhiDelhiIndia
  2. 2.Division of Immunology, Allergy and RheumatologyUniversity of Oregon Health Sciences CentrePortlandUSA

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