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Synthesis of 6-substituted 9-(dihydroxyalkyl) purines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

5-Amino-6-chloro-4-dihydroxyalkylaminopyrimidines, which are cyclized to 6-chloro-9-(dihydroxyalkyl)purines, were obtained by the condensation of 5-amino-4,6-dichloropyrimidine with 2-amino-1,3-dihydroxypropane or with 2-amino-1,4-dihydroxybutane. The corresponding 6-hydroxy and 6-amino derivatives were obtained by replacement of the chlorine.

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Literature cited

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Authors and Affiliations

  1. Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, Riga

    M. Yu. Lidak, Ya. Ya. Shluke, B. V. Zarinya & S. E. Poritere

Authors
  1. M. Yu. Lidak
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  2. Ya. Ya. Shluke
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  3. B. V. Zarinya
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  4. S. E. Poritere
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 262–264, February, 1971.

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Lidak, M.Y., Shluke, Y.Y., Zarinya, B.V. et al. Synthesis of 6-substituted 9-(dihydroxyalkyl) purines. Chem Heterocycl Compd 7, 240–242 (1971). https://doi.org/10.1007/BF00473098

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  • DOI: https://doi.org/10.1007/BF00473098

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