Chemistry of Heterocyclic Compounds

, Volume 26, Issue 3, pp 264–265 | Cite as

Improved method for synthesis of 7-amino-4-methylcoumarin

  • V. F. Pozdnev
Article

Abstract

A new variant of the synthesis of 7-amino-4-methyl-coumarin from m-aminophenol via a three-step scheme is proposed. Acylation of m-aminophenyl with methoxycarbonyl chloride gave m-(N-methoxycarbonylamino)phenol, which was converted to 7-(N-methoxycarbonyl-amino)-4-methylcoumarin by condensation with acetoacetic ester in sulfuric acid. Heating of the coumarin with concentrated alkali leads to an intermediate, which, after acidification, is converted to 7-amino-4-methylcoumarin in high yield.

Keywords

Chloride Ester Phenol Organic Chemistry Sulfuric Acid 

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Copyright information

© Plenum Publishing Corporation 1990

Authors and Affiliations

  • V. F. Pozdnev
    • 1
  1. 1.Institute of Biological and Medicinal ChemistryAcademy of Medical Sciences of the USSRMoscow

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