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Chemistry of Heterocyclic Compounds

, Volume 26, Issue 3, pp 264–265 | Cite as

Improved method for synthesis of 7-amino-4-methylcoumarin

  • V. F. Pozdnev
Article

Abstract

A new variant of the synthesis of 7-amino-4-methyl-coumarin from m-aminophenol via a three-step scheme is proposed. Acylation of m-aminophenyl with methoxycarbonyl chloride gave m-(N-methoxycarbonylamino)phenol, which was converted to 7-(N-methoxycarbonyl-amino)-4-methylcoumarin by condensation with acetoacetic ester in sulfuric acid. Heating of the coumarin with concentrated alkali leads to an intermediate, which, after acidification, is converted to 7-amino-4-methylcoumarin in high yield.

Keywords

Chloride Ester Phenol Organic Chemistry Sulfuric Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1990

Authors and Affiliations

  • V. F. Pozdnev
    • 1
  1. 1.Institute of Biological and Medicinal ChemistryAcademy of Medical Sciences of the USSRMoscow

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