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New method for predicting the antibacterial properties of semisynthetic penicillins.

1. Logical structural analysis

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A new method for predicting the antibacterial properties of semisynthetic penicillins based on statistical evaluation of the merit of including functional groups, heteroatoms, and cyclic systems in fixed positions on the side chain of antibiotics is proposed.

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Literature Cited

  1. C. Hansch and E. W. Deutsch, J. Med. Chem., 8, 706 (1965).

    Google Scholar 

  2. B. Wetzel, E. Weitin, W. Reuter, R. Maier, and U. Lechner, Artzneim.-Forsch., 35, (1A), 343 (1985).

    Google Scholar 

  3. J. U. Indelicato, A. Dinner, L. R. Peters, and W. L. Wilham, J. Med. Chem., 20, 961 (1977).

    Google Scholar 

  4. B. Coene, A. Schanck, J. M. Dereppe, and M. V. Meerssche, J. Med. Chem., 27, 694 (1984).

    Google Scholar 

  5. D. B. Boyd, J. Med. Chem., 27, 63 (1984).

    Google Scholar 

  6. A. B. Rozenblit and V. E. Golender, Logical Combination Methods in Construction of Medicines [in Russian], Zinatne, Riga (1983).

    Google Scholar 

  7. H. Ferres, M. J. Basker, and P. J. O'Hanlon, J. Antibiot., 27, 922 (1974).

    Google Scholar 

  8. J. R. E. Hoover, Handbook of Experimental Pharmacology, Pt. 2, 67, 131 (1983).

    Google Scholar 

  9. N. Oi, B. Aoki, T. Shinozaki, K. Moro, I. Matsunaka, T. Noto, T. Nebashi, J. Harada, and H. Enso, U.S. Pat. No. 4229348, Chem. Abstr., 92, 198392 (1980).

    Google Scholar 

  10. K. G. Metzger and G. Schmidt, U.S. Pat. 3954730, Chem. Abstr., 83, 97277 (1975).

    Google Scholar 

  11. Y. Fujimoto and Y. Kishi, U.S. Pat. No. 4219477, Chem. Abstr., 91, 140857 (1979).

    Google Scholar 

  12. I. Saikawa, S. Takano, C. Yoshida, O. Takashima, K. Momonoi, S. Kuroda, M. Komatsu, T. Yasuda, and Y. Kodama, DE. Pat. No. 2519400, Chem. Abstr., 85, 33052 (1976).

    Google Scholar 

  13. A. Lutz and K. Volger, GB Pat. No. 1348198, Chem. Abstr., 79, 92208 (1973).

    Google Scholar 

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Authors and Affiliations

  1. Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, 226006, Riga

    G. A. Veinberg, A. M. Kats, L. S. Gitlina, V. E. Golender, A. B. Rozenblit & É. Lukevits

Authors
  1. G. A. Veinberg
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  2. A. M. Kats
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  3. L. S. Gitlina
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  4. V. E. Golender
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  5. A. B. Rozenblit
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  6. É. Lukevits
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 396–403, March, 1989.

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Veinberg, G.A., Kats, A.M., Gitlina, L.S. et al. New method for predicting the antibacterial properties of semisynthetic penicillins.. Chem Heterocycl Compd 25, 332–338 (1989). https://doi.org/10.1007/BF00472397

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  • DOI: https://doi.org/10.1007/BF00472397

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