Chemistry of Heterocyclic Compounds

, Volume 27, Issue 8, pp 825–830 | Cite as

Heterocyclic bioantioxidants 1. Reaction of 3-nitro-4-chlorocoumarin with thiolating agents

  • É. A. Parfenov
  • L. D. Smirnov


The reaction of 3-nitro-4-chlorocoumarin with thiolating agents in the presence of water leads to the formation of a mixture of 3-nitro-4-hydroxycoumarin, bis(3-nitro-4-coumarinyl) sulfide, and colored labile products of undetermined structure. The reaction path can be controlled by the choice of solvent, reagent ratio, and temperature regime and by the use of weakly basic additives.


Sulfide Organic Chemistry Temperature Regime Reaction Path Basic Additive 
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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • É. A. Parfenov
    • 1
  • L. D. Smirnov
    • 1
  1. 1.All-Union Scientific Center of the Safety of Biologically Active SubstancesKupavna, Moskovsk Region

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