Abstract
The possibility of using certain ketimines in place of mixtures of ketone and amine in the synthesis of indoles from 3-nitropyridinium salts has been demonstrated. The use of ketimines leads, in many cases, to increased yields of indoles and simplifies their isolation. It has been established that the rate of indole formation is considerably increased in polar aprotic solvents.
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For Communication 3, see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1625–1628, December, 1987.
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Yurovskaya, M.A., Afanas'ev, A.Z., Chertkov, V.A. et al. Synthesis of indoles from pyridinium salts. 4. Ketimines in the synthesis of indoles from 3-nitropyridinium salts. Chem Heterocycl Compd 23, 1305–1308 (1987). https://doi.org/10.1007/BF00472252
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DOI: https://doi.org/10.1007/BF00472252