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Acid-base properties of indolylglyoxal and some acetylindoles

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A spectrophotometric study of the acid-base properties of 3-acylindoles showed that they were stronger acids than the alkylindoles. It was found that protonation of these compounds occurs at the carbonyl group. For indolylglyoxal, 3-acetylindole, and 1-methyl-3-acetylindole the pKb was determined; the pKafor indolylglyoxal and 3-acetylindole was measured in 50% aqueous methanol.

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Authors and Affiliations

  1. Irkutsk Institute of Organic Chemistry, Siberian Branch, Academy of Sciences of the USSR, 664033, Irkutsk

    A. L. Vereshchagin, N. N. Pogodaeva & A. A. Semenov

Authors
  1. A. L. Vereshchagin
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  2. N. N. Pogodaeva
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  3. A. A. Semenov
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Additional information

Translated from Khimiya Geterotsiklicheskhikh Soedinenii, No. 12, pp. 1621–1624, December, 1987.

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Vereshchagin, A.L., Pogodaeva, N.N. & Semenov, A.A. Acid-base properties of indolylglyoxal and some acetylindoles. Chem Heterocycl Compd 23, 1302–1304 (1987). https://doi.org/10.1007/BF00472251

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  • DOI: https://doi.org/10.1007/BF00472251

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