Chemistry of Heterocyclic Compounds

, Volume 26, Issue 10, pp 1164–1167 | Cite as

Electrophilic and nucleophilic substitution in oxazolo[3,2-f]xanthines

  • S. N. Garmash
  • E. A. Skul'skaya
  • B. A. Priimenko
  • N. A. Klyuev
Article

Abstract

Bromination of 2-aryloxazolo[3,2-flxanthines gives the 3-bromoderivatives whereas 8-methyl-2-phenyloxazolo[3,2-f]xanthine is nitrated in the para-position of the phenyl substituent. Alkylation of oxazolo[3,2-f]xanthines by ethylmonoiodoacetate gives the ethyl esters of oxazolo[3,2-f]xanthinyl-6-acetic acids. Reaction of oxazolo[3,2-f]xanthines with sodium sulfide gives thiazolo[3,2-f]xanthines whereas the reaction with secondary amines opens the oxazole ring.

Keywords

Sodium Nitrate Ester Ethyl Sulfide 

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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • S. N. Garmash
    • 1
  • E. A. Skul'skaya
    • 1
  • B. A. Priimenko
    • 1
  • N. A. Klyuev
    • 1
  1. 1.Zaporozh'e Institute of MedicineZaporozh'e

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