Chemistry of Heterocyclic Compounds

, Volume 8, Issue 11, pp 1380–1382 | Cite as

Azaindole derivatives

XLI. Synthesis of 3-substituted 5-azaindoles
  • L. N. Yakhontov
  • E. I. Lapan


Electrophilic substitution reactions — cyanomethylation, bromination, nitration, and the Mannich reaction- in the 5-azaindole series were studied. It is shown that, despite the literature data, 5-azaindole behaves like the isomeric 4- and 7-azaindoles in these reactions. Conditions that make it possible to synthesize various 3-substituted 5-azaindoles in high yields were found.


Organic Chemistry Nitration Substitution Reaction Electrophilic Substitution Mannich Reaction 
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Copyright information

© Plenum Publishing Corporation 1974

Authors and Affiliations

  • L. N. Yakhontov
    • 1
  • E. I. Lapan
    • 1
  1. 1.S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical-Chemistry InstituteMoscow

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