Chemistry of Heterocyclic Compounds

, Volume 14, Issue 7, pp 725–727 | Cite as

Structures of bromo-substituted pyrone-4-carboxylic acids obtained by direct bromination

  • G. A. Khutornenko
  • S. G. Rozenberg
  • A. E. Vasil'ev


Ethyl esters of mono- and dibromocomanic acid were obtained by direct bromination, and the corresponding acids were obtained from the esters by acid hydrolysis. The structures of the compounds obtained and of the previously synthesized bromo-substituted comanic acid were established, and it was proved that the attack of bromine is directed to the 5-C and 3-C atoms; attack takes place first at the more nucleophilic 5-C center, after which the 3-C atom undergoes attack.


Ester Hydrolysis Ethyl Organic Chemistry Bromine 
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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • G. A. Khutornenko
    • 1
  • S. G. Rozenberg
    • 1
  • A. E. Vasil'ev
    • 1
  1. 1.Scientific-Research Institute of PharmacologyAcademy of Medical Sciences of the USSRMoscow

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