Abstract
It has been found that a decrease in the yield of α-substituted products during alkylation with olefins is observed in a number of five-membered heterocycles (furan, thiophene, and N-methylpyrrole). The change in the α-orienting effect depends not only on the nature of the heteroatom but also on the type of reaction and on the conditions of the process. In the case of N-methylpyrrole, the possibility of C-alkylation of the pyrrole ring with olefins was demonstrated for the first time.
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Additional information
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 502–506, April, 1973.
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Lebedev, B.L., Korytina, O.A. & Petrovskaya, L.I. Substitution in a number of five-membered heterocycles with one heteroatom catalytic alkylation of N-methylpyrrole and thiophene with olefins. Chem Heterocycl Compd 9, 462–466 (1973). https://doi.org/10.1007/BF00471526
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DOI: https://doi.org/10.1007/BF00471526