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Cleavage of arylhydrazones of α-hydroxyketones at the N-N bond with acetic acid in the presence of O-phenylenediamine formation of quinoxalines

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Abstract

The corresponding quinoxalines are formed by the reaction of arylhydrazones of α-hydroxyketones with o-phenylenediamine in glacial acetic acid. The basis for the reaction is the ability of arylhydrazones of α-hydroxycarbonyl compounds to undergo cleavage at the N-N bond in carboxylic acid media to form an arylamine and an α-diketone monoimine.

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Authors and Affiliations

  1. Institute of Biological and Medicinal Chemistry, Academy of Medical Sciences of the USSR, Moscow

    K. M. Ermolaev

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  1. K. M. Ermolaev
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 540–542, April, 1971.

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Ermolaev, K.M. Cleavage of arylhydrazones of α-hydroxyketones at the N-N bond with acetic acid in the presence of O-phenylenediamine formation of quinoxalines. Chem Heterocycl Compd 7, 504–506 (1971). https://doi.org/10.1007/BF00471495

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  • DOI: https://doi.org/10.1007/BF00471495

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