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Indole derivatives

XCIII. Synthesis of 5-(3-indolylmethyl)barbituric and 5-(3-indolylmethyl)thiobarbituric acids

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

5-(3-Indolylmethyl)barbituric and 5-(3-indolylmethyl)thiobarbituric acids were obtained by condensation of 3-indolylmethylmalonic ester with urea and thiourea in monoglyme (1,2-di-methoxyethane) in the presence of lithium methoxide. The first of the two acids was also obtained by catalytic hydrogenation of 5- (3-indolylmethylene)barbituric acid.

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Literature cited

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Authors and Affiliations

  1. D. I. Mendeleev Moscow Institute of Chemical Technology, USSR

    N. N. Suvorov, V. S. Velezheva & V. V. Vampilova

Authors
  1. N. N. Suvorov
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  2. V. S. Velezheva
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  3. V. V. Vampilova
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Additional information

See [1] for communication XCII.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 646–649, May, 1974.

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Suvorov, N.N., Velezheva, V.S. & Vampilova, V.V. Indole derivatives. Chem Heterocycl Compd 10, 559–562 (1974). https://doi.org/10.1007/BF00471327

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  • DOI: https://doi.org/10.1007/BF00471327

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