Abstract
Continuing investigations in the field of the synthesis of condensed heterocyclic systems containing pyrrole and indole fragments ¦1–3¦, we have condensed of 2-aminopyrrole derivatives with various 1, 3-dicarbonyl compounds. The reaction took place at the boil in solutions in pyridine or acetic acid, and also without a solvent at 150–160° C, forming in a single stage derivatives of pyrrolo[1, 2-a]pyrimidine (I–III) and pyrrolo[2, 1-b]-tetrahydroquinazoline (IV–VI). The condensation of 2-aminopyrrole with acetoacetic and substituted acetoacetic esters led to 4-oxo derivatives of pyrrolo[1, 2-β]pyrimidine (VII and VIII).
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References
V. I. Shvedov, L. B. Altukhova, and A. N. Grinev, KhFZh, no. 3, 25, 1967.
V. I. Shvedov, V. V. Alekseev, L. B. Altukhova, and A. N. Grinev, KhFZh, no. 12, 3, 1968.
V. I. Shvedov, L. B. Altukhova, and A. N. Grinev, KhGS [Chemistry of Heterocyclic Compounds], 5, 761, 1969.
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Shvedov, V.I., Kharizomenova, I.A., Altukhova, L.B. et al. Synthesis of derivatives of pyrrolo[1, 2-α]pyrmidine. Chem Heterocycl Compd 6, 400 (1970). https://doi.org/10.1007/BF00471253
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DOI: https://doi.org/10.1007/BF00471253